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HLA-Fatal attraction

Open conformers of the non-classical and monomorphic major histocompatibility complex (MHC) class I molecule HLA-F are ligands for the activating receptor KIR3DS1 and trigger the activation of natural killer (NK) cells.

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Figure 1: Open conformers of HLA-F further expand the list of ligands for activating KIRs.

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Correspondence to Eric Vivier.

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E.V. is a co-founder and shareholder of Innate-Pharma.

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Vély, F., Golub, R. & Vivier, E. HLA-Fatal attraction. Nat Immunol 17, 1012–1014 (2016). https://doi.org/10.1038/ni.3541

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