Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Mitochondria provide a 'complex' solution to a bacterial problem

Nature Immunology volume 17, pages 1009–1010 (2016)Cite this article

Subjects

Adaptations in the mitochondrial electron-transport chain mediate antibacterial responses in macrophages.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: A mitochondrial arsenal against bacteria in macrophages.

Marina Corral Spence/Nature Publishing Group

References

  1. Shadel, G.S. & Horvath, T.L. Cell 163, 560–569 (2015).

    Article  CAS  Google Scholar 

  2. Weinberg, S.E., Sena, L.A. & Chandel, N.S. Immunity 42, 406–417 (2015).

    Article  CAS  Google Scholar 

  3. West, A.P., Shadel, G.S. & Ghosh, S. Nat. Rev. Immunol. 11, 389–402 (2011).

    Article  CAS  Google Scholar 

  4. Garaude, J. et al. Nat. Immunol. 17, 1037–1045 (2016).

    Article  CAS  Google Scholar 

  5. Acin-Perez, R. & Enriquez, J. A. Biochim. Biophys. Acta–Bioenerg. 1837, 444–450 (2014).

    Article  CAS  Google Scholar 

  6. Brandes, R.P., Weissmann, N. & Schröder, K. Free Radic. Biol. Med. 76, 208–226 (2014).

    Article  CAS  Google Scholar 

  7. West, A.P. et al. Nature 472, 476–480 (2011).

    Article  CAS  Google Scholar 

  8. West, A.P. et al. Nature 520, 553–557 (2015).

    Article  Google Scholar 

  9. Jabir, M.S. et al. Autophagy 11, 166–182 (2015).

    Article  Google Scholar 

  10. Andrade, W.A. et al. Cell Rep. 15, 2438–2448 (2016).

    Article  CAS  Google Scholar 

  11. Woodward, J. J., Iavarone, A. T. & Portnoy, D. A. Science 328, 1703–1705 (2010).

    Article  CAS  Google Scholar 

  12. Shaw, A.C., Goldstein, D.R. & Montgomery, R.R. Nat. Rev. Immunol. 13, 875–887 (2013).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Marissa A. Holmbeck is in the Department of Pathology, Yale School of Medicine, New Haven, Connecticut, USA.,

    Marissa A Holmbeck

  2. Gerald S. Shadel is in the Department of Pathology, the Department of Genetics, Yale School of Medicine, New Haven, Connecticut, USA, Yale School of Medicine, New Haven, Connecticut, USA, and the Yale Center for Research on Aging New Haven, Connecticut, USA.,

    Gerald S Shadel

Authors
  1. Marissa A Holmbeck
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Gerald S Shadel
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Gerald S Shadel.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Holmbeck, M., Shadel, G. Mitochondria provide a 'complex' solution to a bacterial problem. Nat Immunol 17, 1009–1010 (2016). https://doi.org/10.1038/ni.3534

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ni.3534

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing