Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Bach2 is required for B cell and T cell memory differentiation

Nature Immunology volume 17, pages 744–745 (2016)Cite this article

Subjects

B cell and T cell memory differentiation requires the transcription factor Bach2, which inhibits the effector-cell fate by limiting antigen-receptor-stimulation-induced gene expression and restricting premature expression of the transcriptional regulator Blimp-1.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Bach2 regulates lymphocyte effector-versus-memory fate 'decisions'.

References

  1. Shinnakasu, R. et al. Nat. Immunol. 17, 861–869 (2016).

    Article  CAS  PubMed  Google Scholar 

  2. Roychoudhuri, R. et al. Nat. Immunol. 17, 851–860 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Phan, T.G. et al. J. Exp. Med. 203, 2419–2424 (2006).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Weisel, F.J., Zuccarino-Catania, G.V., Chikina, M. & Shlomchik, M.J.A. Immunity 44, 116–130 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Toyama, H. et al. Immunity 17, 329–339 (2002).

    Article  CAS  PubMed  Google Scholar 

  6. Zotos, D. et al. J. Exp. Med. 207, 365–378 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Muto, A. et al. Nature 429, 566–571 (2004).

    Article  CAS  PubMed  Google Scholar 

  8. Muto, A. et al. EMBO J. 29, 4048–4061 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Kallies, A. & Nutt, S.L. Curr. Opin. Immunol. 19, 156–162 (2007).

    Article  CAS  PubMed  Google Scholar 

  10. Roychoudhuri, R. et al. Nature 498, 506–510 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Tanaka, H. et al. J. Biol. Chem. 291, 6316–6330 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Grötsch, B. et al. J. Exp. Med. 211, 2199–2212 (2014).

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Tom Sidwell and Axel Kallies are at The Walter and Eliza Hall Institute of Medical Research and the University of Melbourne, Parkville, Australia.,

    Tom Sidwell & Axel Kallies

Authors
  1. Tom Sidwell
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Axel Kallies
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Axel Kallies.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Sidwell, T., Kallies, A. Bach2 is required for B cell and T cell memory differentiation. Nat Immunol 17, 744–745 (2016). https://doi.org/10.1038/ni.3493

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ni.3493

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing