Supplementary Figure 6: Gene-interaction networks for significantly deregulated gene probes from day-11 TDLNs. | Nature Immunology

Supplementary Figure 6: Gene-interaction networks for significantly deregulated gene probes from day-11 TDLNs.

From: Tumor-induced stromal reprogramming drives lymph node transformation

Supplementary Figure 6

The MANIA algorithm includes 3 edge types between nodes: Predicted Edges, which implies functional relationships due to orthology with other organisms (gold), Co-localization Edges, where linked gene products are expressed in the same cellular location (blue), and Co-expression edges, where the expression levels of gene products are similar across conditions in a previously published gene expression study (pink). Node color also indicates whether a gene is predicted to be involved in the network (grey), or is one of the input genes (blue). Genes are linked through calculated edges, and networks of linked genes generated. The four most relevant probe groups are shown; all are involved in cell structure or shape. Models predict a large degree of relatedness and significance between Extracellular Matrix Proteins, Microtubule Cytoskeletal Elements, and Microtubule Regulation. Less dense networks (Structural Proteins) indicate less specific functional annotation.

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