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Eosinophils and mast cells: a lineage apart

Single-cell transcriptome analysis has identified progenitor populations with mast-cell and eosinophil potential that are distinct from the neutrophil-monocyte lineage, segregate early in hematopoietic development and can be discriminated by expression of the transcription factor GATA-1.

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Figure 1: Current and revised models of granulopoiesis.


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Correspondence to Michael H Sieweke.

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Sarrazin, S., Sieweke, M. Eosinophils and mast cells: a lineage apart. Nat Immunol 17, 609–611 (2016).

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