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A dendritic cell subset designed for oral tolerance

Nature Immunology volume 17, pages 474–476 (2016)Cite this article

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Studies using genetic tools have identified the distinct dendritic cell subsets that ensure tolerance to oral antigens in the antigen-rich environment of the gut and suggest a 'division of labor' for protective immunity.

Important efforts have been made to delineate the roles of individual dendritic cell (DC) subsets and macrophages in immunotolerance and protective immunity. How oral tolerance is established and how peripheral regulatory T cells (pTreg cells) are induced in an antigen-rich environment, with constant challenge by pathogens, remain questions of substantial importance. In this issue of Nature Immunology, Esterházy et al. use several genetic approaches to delineate the role of intestinal DC and macrophage subsets in oral tolerance, using ovalbumin (OVA) as a model oral antigen1.

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Figure 1: mLN DC subsets in immunotolerance and protective immunity.

Katie Vicari/Nature Publishing Group

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Authors and Affiliations

  1. Reinhard Hinterleitner and Bana Jabri are in the Department of Medicine, Committee on Immunology, The University of Chicago, Chicago, Illinois, USA.,

    Reinhard Hinterleitner & Bana Jabri

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  1. Reinhard Hinterleitner
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  2. Bana Jabri
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Correspondence to Bana Jabri.

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The authors declare no competing financial interests.

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Hinterleitner, R., Jabri, B. A dendritic cell subset designed for oral tolerance. Nat Immunol 17, 474–476 (2016). https://doi.org/10.1038/ni.3435

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