The accumulation of intestinal Foxp3+ regulatory T cells (Treg cells) in response to the microbiota is tightly regulated. Epithelial apoptosis inhibits the production of tolerogenic interferon-β by myeloid cells and thereby reduces the frequency of Treg cells and lowers the threshold for inflammatory responses.
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Pott, J., Maloy, K. & Izcue, A. Barrier regulation: tolerance stops at cell death. Nat Immunol 17, 349–350 (2016). https://doi.org/10.1038/ni.3418
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DOI: https://doi.org/10.1038/ni.3418
