The NEK-sus of the NLRP3 inflammasome

The NLRP3 inflammasome has broad biomedical relevance, but its activation mechanisms are incompletely understood. NEK7, a kinase that regulates microtubules during mitosis, is identified as a critical and selective upstream regulator of NLRP3 inflammasome activation.

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Figure 1: Model of NEK7 signaling in activation of the NLRP3 inflammasome.

Marina Corral Spence/Nature Publishing Group

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Correspondence to Mohamed Lamkanfi.

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Van Hauwermeiren, F., Lamkanfi, M. The NEK-sus of the NLRP3 inflammasome. Nat Immunol 17, 223–224 (2016). https://doi.org/10.1038/ni.3391

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