Trabid epigenetically drives expression of IL-12 and IL-23

The production of interleukin 12 (IL-12) and IL-23 in dendritic cells is strictly regulated via epigenetic silencing. This transcriptional repression is overcome with the help of the deubiquitinase Trabid and has functional implications in a mouse model of multiple sclerosis.

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Figure 1: Model for the role of Trabid in epigenetic regulation of Il12b expression.

Marina Corral Spence/Nature Publishing Group

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Correspondence to Rudi Beyaert.

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Afonina, I., Beyaert, R. Trabid epigenetically drives expression of IL-12 and IL-23. Nat Immunol 17, 227–228 (2016). https://doi.org/10.1038/ni.3388

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