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Trabid epigenetically drives expression of IL-12 and IL-23

Nature Immunology volume 17, pages 227–228 (2016)Cite this article

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The production of interleukin 12 (IL-12) and IL-23 in dendritic cells is strictly regulated via epigenetic silencing. This transcriptional repression is overcome with the help of the deubiquitinase Trabid and has functional implications in a mouse model of multiple sclerosis.

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Figure 1: Model for the role of Trabid in epigenetic regulation of Il12b expression.

Marina Corral Spence/Nature Publishing Group

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Authors and Affiliations

  1. and the Department of Biomedical Molecular Biology, Inna S. Afonina and Rudi Beyaert are with the Inflammation Research Center (VIB), Ghent University, Ghent, Belgium.,

    Inna S Afonina & Rudi Beyaert

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  1. Inna S Afonina
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  2. Rudi Beyaert
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Correspondence to Rudi Beyaert.

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Afonina, I., Beyaert, R. Trabid epigenetically drives expression of IL-12 and IL-23. Nat Immunol 17, 227–228 (2016). https://doi.org/10.1038/ni.3388

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