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Multilayered ancestry of arterial macrophages

Nature Immunology volume 17, pages 117–118 (2016)Cite this article

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Arteries are colonized by macrophages of multiple origins, derived prenatally from the yolk sac and during an early postnatal wave from the bone marrow. During sepsis, blood monocyte-derived macrophages transiently contribute to, but do not replace, resident arterial macrophages that largely self-renew in situ.

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Figure 1: Origins of arterial macrophages in development, at steady state and during arterial inflammation.

Marina Corral Spence/Nature Publishing Group

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Authors and Affiliations

  1. Kay Klapproth and Hans-Reimer Rodewald are in the Division of Cellular Immunology, German Cancer Research Center, Heidelberg, Germany.,

    Kay Klapproth & Hans-Reimer Rodewald

  2. Felix Lasitschka is in the Department of Pathology, University Hospital Heidelberg, Heidelberg, Germany.,

    Felix Lasitschka

Authors
  1. Kay Klapproth
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  2. Felix Lasitschka
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  3. Hans-Reimer Rodewald
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Correspondence to Hans-Reimer Rodewald.

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Klapproth, K., Lasitschka, F. & Rodewald, HR. Multilayered ancestry of arterial macrophages. Nat Immunol 17, 117–118 (2016). https://doi.org/10.1038/ni.3374

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