Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Fatty acid oxidation in macrophage polarization

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: Macrophage FAO is not required for M2 polarization.

References

  1. Odegaard, J.I. & Chawla, A. Immunity 38, 644–654 (2013).

    CAS  Article  Google Scholar 

  2. Pearce, E.L. & Pearce, E.J. Immunity 38, 633–643 (2013).

    CAS  Article  Google Scholar 

  3. Vats, D. et al. Cell Metab. 4, 13–24 (2006).

    CAS  Article  Google Scholar 

  4. Huang, S.C. et al. Nat. Immunol. 15, 846–855 (2014).

    CAS  Article  Google Scholar 

  5. Houten, S.M. & Wanders, R.J. J. Inherit. Metab. Dis. 33, 469–477 (2010).

    CAS  Article  Google Scholar 

  6. Lee, J., Ellis, J.M. & Wolfgang, M.J. Cell Rep. 10, 266–279 (2015).

    CAS  Article  Google Scholar 

  7. Namgaladze, D. & Brune, B. Biochim. Biophys. Acta 1841, 1329–1335 (2014).

    CAS  Article  Google Scholar 

  8. Lee, J., Ellis, J.M. & Wolfgang, M.J. Cell Rep 10, 266–279 (2015).

    CAS  Article  Google Scholar 

  9. Clausen, B.E., Burkhardt, C., Reith, W., Renkawitz, R. & Forster, I. Transgenic Res. 8, 265–277 (1999).

    CAS  Article  Google Scholar 

  10. Samali, A., Cai, J., Zhivotovsky, B., Jones, D.P. & Orrenius, S. EMBO J. 18, 2040–2048 (1999).

    CAS  Article  Google Scholar 

  11. Jenkins, S.J. et al. Science 332, 1284–1288 (2011).

    CAS  Article  Google Scholar 

Download references

Acknowledgements

Supported by The US National Institutes of Health (Intramural Funds; and NS072241 for M.J.W.), Fondation Leducq (T.F.) and Japan Society for the Promotion of Science (M.N.).

Author information

Authors and Affiliations

Authors

Contributions

M.N. and J.L. performed the experiments; M.N., I.I.R., E.G.-H., J.L., M.J.W. and T.F. analyzed the data; and M.N. and T.F. wrote the manuscript.

Corresponding authors

Correspondence to Michael J Wolfgang or Toren Finkel.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Integrated supplementary information

Supplementary Figure 1 Transport of long-chain fatty acids into the mitochondrial matrix.

Schematic demonstrating the role of CPT1 located on the outer mitochondrial membrane (OMM) and CPT2 on the inner mitochondrial membrane (IMM) in transporting long chain FAs in the form of Acyl-CoA into the mitochondrial matrix. The drug etomoxir is thought to function as a CPT1 inhibitor.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Nomura, M., Liu, J., Rovira, I. et al. Fatty acid oxidation in macrophage polarization. Nat Immunol 17, 216–217 (2016). https://doi.org/10.1038/ni.3366

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ni.3366

Further reading

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing