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O-linked sugars sound the alarm

Nature Immunology volume 17, pages 119120 (2016) | Download Citation

Viral infection of the mucosa induces a strong host innate immune response involving type I interferons and interferon-stimulated genes. New findings show that mechanical or pathogen-induced disruption of the mucus itself can also trigger 'hyper-early' innate responses independent of type I interferons and major sensing pathways of the innate immune system.

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References

  1. 1.

    Nat. Rev. Immunol. 10, 699–711 (2010).

  2. 2.

    et al. J. Reprod. Immunol. 88, 210–218 (2011).

  3. 3.

    et al. Nat. Immunol. 17, 150–158 (2016).

  4. 4.

    & J. Virol. 83, 9486–9501 (2009).

  5. 5.

    et al. Nature 462, 510–513 (2009).

  6. 6.

    et al. J. Immunol. 177, 7510–7514 (2006).

  7. 7.

    & Trends Immunol. 32, 151–156 (2011).

  8. 8.

    et al. J. Immunol. 156, 128–135 (1996).

  9. 9.

    et al. Sex. Transm. Infect. 77, 402–408 (2001).

  10. 10.

    et al. J. Clin. Invest. 122, 2711–2719 (2012).

  11. 11.

    , & J. Reprod. Immunol. 49, 49–65 (2001).

  12. 12.

    et al. Am. J. Respir. Crit. Care Med. 187, 65–77 (2013).

  13. 13.

    et al. Glycobiology 23, 1038–1046 (2013).

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Author information

Affiliations

  1. Smita Gopinath, Yosuke Kumamoto and Akiko Iwasaki are in the Department of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut, USA.

    • Smita Gopinath
    • , Yosuke Kumamoto
    •  & Akiko Iwasaki

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Akiko Iwasaki.

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DOI

https://doi.org/10.1038/ni.3364

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