Viral infection of the mucosa induces a strong host innate immune response involving type I interferons and interferon-stimulated genes. New findings show that mechanical or pathogen-induced disruption of the mucus itself can also trigger 'hyper-early' innate responses independent of type I interferons and major sensing pathways of the innate immune system.
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Gopinath, S., Kumamoto, Y. & Iwasaki, A. O-linked sugars sound the alarm. Nat Immunol 17, 119–120 (2016). https://doi.org/10.1038/ni.3364
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DOI: https://doi.org/10.1038/ni.3364
