Putting the brakes on ILC2 cells

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Immune responses are characterized by the concerted actions of both effector mechanisms and regulatory mechanisms. Signaling via the transcription factor STAT1 downstream of receptors for interferons and interleukin 27 (IL-27) can suppress type 2 immune responses induced by group 2 innate lymphoid cells (ILCs).

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Figure 1: STAT1 regulates ILC2 cells.

References

  1. 1

    Spits, H. et al. Nat. Rev. Immunol. 13, 145–149 (2013).

  2. 2

    Molofsky, A.B. et al. J. Exp. Med. 210, 535–549 (2013).

  3. 3

    Finotto, S. et al. Science 295, 336–338 (2002).

  4. 4

    Huber, J.P. & Farrar, J.D. Immunology 132, 466–474 (2011).

  5. 5

    Cohn, L. et al. J. Exp. Med. 190, 1309–1318 (1999).

  6. 6

    Duerr, C.U et al. Nat. Immunol. 17, 65–75 (2016).

  7. 7

    Moro, K. et al. Nat. Immunol. 17, 76–86 (2016).

  8. 8

    Gasteiger, G. et al. Science 350, 981–985 (2015).

  9. 9

    Molofsky, A.B. et al. Immunity 43, 161–174 (2015).

  10. 10

    Chang, Y.J. et al. Nat. Immunol. 12, 631–638 (2011).

  11. 11

    Turner, J.E. et al. J. Exp. Med. 210, 2951–2965 (2013).

  12. 12

    Monticelli, L.A. et al. Nat. Immunol. 12, 1045–1054 (2011).

  13. 13

    Zhu, J. & Paul, W.E. Immunol. Rev. 238, 247–262 (2010).

  14. 14

    Lucas, S. et al. Proc. Natl. Acad. Sci. USA 100, 15047–15052 (2003).

  15. 15

    Szabo, S.J. et al. Cell 100, 655–669 (2000).

  16. 16

    Hegazy, A.N. Immunity 32, 116–128 (2010).

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Correspondence to Chiara Romagnani.

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The authors declare no competing financial interests.

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Stehle, C., Saikali, P. & Romagnani, C. Putting the brakes on ILC2 cells. Nat Immunol 17, 43–44 (2016) doi:10.1038/ni.3353

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