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The cell identity of cytotoxic T lymphocytes

Nature Immunology volume 17, pages 45–46 (2016)Cite this article

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Understanding cytotoxic T cells has been a major focus of immunology research for decades. Proteomic profiling of these cells now brings them into unprecedented and revealing focus.

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Figure 1: Cell identity of CTLs.

References

  1. Schwanhäusser, B. et al. Nature 473, 337–342 (2011).

    Google Scholar 

  2. Hukelmann, J.L. et al. Nat. Immunol. 17, 104–112 (2016).

    Article  CAS  Google Scholar 

  3. Wiśniewski, J.R., Hein, M.Y., Cox, J. & Mann, M. Mol. Cell. Proteomics 13, 3497–3506 (2014).

    Article  Google Scholar 

  4. Isaaz, S., Baetz, K., Olsen, K., Podack, E. & Griffiths, G.M. Eur. J. Immunol. 25, 1071–1079 (1995).

    Article  CAS  Google Scholar 

  5. Buck, D., O'Sullivan, D. & Pearce, E.L. J. Exp. Med. 212, 1345–1360 (2015).

    Article  CAS  Google Scholar 

  6. Cham, C.M., Driessens, G., O'Keefe, J.P. & Gajewski, T.F. Eur. J. Immunol. 38, 2438–2450 (2008).

    Article  CAS  Google Scholar 

  7. Castello, A., Hentze, M.W. & Preiss, T. Trends Endocrinol. Metab. http://dx.doi.org/10.1016/j.tem.2015.09.012 (28 October 2015).

  8. Macintyre, A.N. et al. Cell Metab. 20, 61–72 (2014).

    Article  CAS  Google Scholar 

  9. Sinclair, L.V. et al. Nat. Immunol. 14, 500–508 (2013).

    Article  CAS  Google Scholar 

  10. Xu, X., Ye, L., Araki, K. & Ahmed, s Semin. Immunol. 24, 429–435 (2012).

    Article  CAS  Google Scholar 

  11. Intlekofer, A.M. et al. Nat. Immunol. 6, 1236–1244 (2005).

    Article  CAS  Google Scholar 

  12. Jha, A.K. et al. Immunity 42, 419–430 (2015).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. David E. Sanin and Edward J. Pearce are in the Department of Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, Freiburg im Breisgau, Germany.,

    David E Sanin & Edward J Pearce

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  1. David E Sanin
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  2. Edward J Pearce
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Correspondence to Edward J Pearce.

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The authors declare no competing financial interests.

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Sanin, D., Pearce, E. The cell identity of cytotoxic T lymphocytes. Nat Immunol 17, 45–46 (2016). https://doi.org/10.1038/ni.3350

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