Glycolysis and EZH2 boost T cell weaponry against tumors

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Low availability of glucose in tumors negatively affects the activity of tumor-infiltrating T cells. Loss of T cell function under these conditions is mediated by the microRNAs miR-101 and miR-26a, which target expression of the methytransferase EZH2 and thereby diminish the expression of anti-tumor cytokines.

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Figure 1: The effect of glucose restriction on the function of tumor infiltrating lymphocytes.

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Correspondence to Christoph Hess.

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Bantug, G., Hess, C. Glycolysis and EZH2 boost T cell weaponry against tumors. Nat Immunol 17, 41–42 (2016) doi:10.1038/ni.3346

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