Review Article | Published:

The development and maintenance of resident macrophages

Nature Immunology volume 17, pages 28 (2016) | Download Citation

Abstract

The molecular and cellular mechanisms that underlie the many roles of macrophages in health and disease states in vivo remain poorly understood. The purpose of this Review is to present and discuss current knowledge on the developmental biology of macrophages, as it underlies the concept of a layered myeloid system composed of 'resident' macrophages that originate mainly from progenitor cells generated in the yolk sac and of 'passenger' or 'transitory' myeloid cells that originate and renew from bone marrow hematopoietic stem cells, and to provide a framework for investigating the functions of macrophages in vivo.

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Acknowledgements

Supported by the National Cancer Institute of the US National Institutes of Health (P30CA008748 to F.G.), the Wellcome Trust (WT101853MA to F.G.), the European Research Council (2010-StG-261299 to F.G.), the Institut Pasteur (E.G.P.) and Agence Nationale de la Recherche (Laboratoire d'Excellence Revive, Investissement d'Avenir; ANR-10-LABX-73 to E.G.P.).

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  1. Macrophages and Endothelial Cells group, Department of Developmental and Stem Cell Biology, CNRS URA 2578, Institut Pasteur, Paris, France.

    • Elisa Gomez Perdiguero
  2. Immunology Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA.

    • Frederic Geissmann

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The authors declare no competing financial interests.

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Correspondence to Frederic Geissmann.

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https://doi.org/10.1038/ni.3341