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Tissue biology perspective on macrophages

Nature Immunology volume 17, pages 917 (2016) | Download Citation

Abstract

Macrophages are essential components of mammalian tissues. Although historically known mainly for their function in host defense and the clearance of apoptotic cells, macrophages are now increasingly recognized as serving many roles in tissue development, homeostasis and repair. In addition, tissue-resident macrophages have many tissue-specific functional characteristics, which are a reflection of distinct gene-expression programs. Here we discuss the emerging views of macrophage biology from evolutionary, developmental and homeostatic perspectives.

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Acknowledgements

We thank members of the Medzhitov laboratory for discussions, and L. Kopp for reading the manuscript. Supported by The Blavatnik Family Foundation, Else Kröner-Fresenius-Stiftung, the US National Institutes of Health (AI046688, AI089771 and CA157461) and the Howard Hughes Medical Institute (all for research in the Medzhitov laboratory).

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Affiliations

  1. Howard Hughes Medical Institute, Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA.

    • Yasutaka Okabe
    •  & Ruslan Medzhitov

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The authors declare no competing financial interests.

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Correspondence to Ruslan Medzhitov.

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DOI

https://doi.org/10.1038/ni.3320