Macrophages are essential components of mammalian tissues. Although historically known mainly for their function in host defense and the clearance of apoptotic cells, macrophages are now increasingly recognized as serving many roles in tissue development, homeostasis and repair. In addition, tissue-resident macrophages have many tissue-specific functional characteristics, which are a reflection of distinct gene-expression programs. Here we discuss the emerging views of macrophage biology from evolutionary, developmental and homeostatic perspectives.
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We thank members of the Medzhitov laboratory for discussions, and L. Kopp for reading the manuscript. Supported by The Blavatnik Family Foundation, Else Kröner-Fresenius-Stiftung, the US National Institutes of Health (AI046688, AI089771 and CA157461) and the Howard Hughes Medical Institute (all for research in the Medzhitov laboratory).
The authors declare no competing financial interests.
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Okabe, Y., Medzhitov, R. Tissue biology perspective on macrophages. Nat Immunol 17, 9–17 (2016). https://doi.org/10.1038/ni.3320
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