Drosha cuts the tethers of myelopoiesis

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The RNA endonuclease Drosha is required for myelopoiesis by its direct cleavage of stem-loop structures in mRNAs encoding Myl9 and Todr1.

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Figure 1: Drosha has a dual role in the biogenesis of miRNA and cleavage of mRNA in myeloid progenitor cells.

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Correspondence to Caetano Reis e Sousa.

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van der Veen, A., Maillard, P. & Reis e Sousa, C. Drosha cuts the tethers of myelopoiesis. Nat Immunol 16, 1110–1112 (2015) doi:10.1038/ni.3297

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