Reversed-polarity Treg cell TCRs provide a shock

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Docking of T cell antigen receptors (TCRs) engaging complexes of peptide and major histocompatibility complex has shown the same diagonal orientation and polarity. A new study demonstrating that TCRs from regulatory T cells bind with reversed polarity challenges this dogma.

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Figure 1: TCR-peptide interactions.

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Correspondence to Mark Peakman or Andrew K Sewell.

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Competing interests

M.P. and King's College London have a license agreement with UCB Pharma to develop a peptide-based immunotherapy for type 1 diabetes.

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Peakman, M., Sewell, A. Reversed-polarity Treg cell TCRs provide a shock. Nat Immunol 16, 1105–1107 (2015) doi:10.1038/ni.3289

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