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To κ+ B or not to κ+ B

Nature Immunology volume 16, pages 10071009 (2015) | Download Citation

Immature B lymphocytes and T lymphocytes assemble antigen receptor–encoding genes in lineage- and developmental stage–specific fashion. New findings show that pre-B cells use specialized locus-specific epigenetic mechanisms to promote recombination of the locus encoding the immunoglobulin κ-chain (Igk) and κ-chain+ B cell development.

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Author information

Affiliations

  1. Megan R. Fisher and Craig H. Bassing are in the Division of Cancer Pathobiology, Department of Pathology and Laboratory Medicine, Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA, and the Immunology Graduate Group, Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.

    • Megan R Fisher
    •  & Craig H Bassing

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Competing interests

C.H.B. is a consultant for Regeneron Pharmaceuticals.

Corresponding author

Correspondence to Craig H Bassing.

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DOI

https://doi.org/10.1038/ni.3277

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