A previously unknown function for TH17 cell–derived IL-26 as a direct antimicrobial agent and activator of DNA-sensing innate immunity is now reported.
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Yang, Y. et al. Nature 510, 152–156 (2014).
Bettelli, E., Korn, T., Oukka, M. & Kuchroo, V.K. Nature 453, 1051–1057 (2008).
Liang, S.C. et al. J. Exp. Med. 203, 2271–2279 (2006).
Meller, S. et al. Nat. Immunol. 16, 970–979 (2015).
Wilson, N.J. et al. Nat. Immunol. 8, 950–957 (2007).
Knappe, A., Hör, S., Wittmann, S. & Fickenscher, H. J. Virol. 74, 3881–3887 (2000).
Zasloff, M. Nature 415, 389–395 (2002).
Rutz, S., Wang, X. & Ouyang, W. Nat. Rev. Immunol. 14, 783–795 (2014).
Lande, R. et al. Nature 449, 564–569 (2007).
Parker, M.W. & Feil, S.C. Prog. Biophys. Mol. Biol. 88, 91–142 (2005).
The authors are employees of Merck.
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Lee, J., Cua, D. IL-26 AMPs up the TH17 arsenal. Nat Immunol 16, 897–898 (2015). https://doi.org/10.1038/ni.3256