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IL-26 AMPs up the TH17 arsenal

A previously unknown function for TH17 cell–derived IL-26 as a direct antimicrobial agent and activator of DNA-sensing innate immunity is now reported.

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Figure 1: AMPs associated with TH17 responses.

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  1. Yang, Y. et al. Nature 510, 152–156 (2014).

    Article  CAS  Google Scholar 

  2. Bettelli, E., Korn, T., Oukka, M. & Kuchroo, V.K. Nature 453, 1051–1057 (2008).

    Article  CAS  Google Scholar 

  3. Liang, S.C. et al. J. Exp. Med. 203, 2271–2279 (2006).

    Article  CAS  Google Scholar 

  4. Meller, S. et al. Nat. Immunol. 16, 970–979 (2015).

    Article  CAS  Google Scholar 

  5. Wilson, N.J. et al. Nat. Immunol. 8, 950–957 (2007).

    Article  CAS  Google Scholar 

  6. Knappe, A., Hör, S., Wittmann, S. & Fickenscher, H. J. Virol. 74, 3881–3887 (2000).

    Article  CAS  Google Scholar 

  7. Zasloff, M. Nature 415, 389–395 (2002).

    Article  CAS  Google Scholar 

  8. Rutz, S., Wang, X. & Ouyang, W. Nat. Rev. Immunol. 14, 783–795 (2014).

    Article  CAS  Google Scholar 

  9. Lande, R. et al. Nature 449, 564–569 (2007).

    Article  CAS  Google Scholar 

  10. Parker, M.W. & Feil, S.C. Prog. Biophys. Mol. Biol. 88, 91–142 (2005).

    Article  CAS  Google Scholar 

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Correspondence to Daniel J Cua.

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The authors are employees of Merck.

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Lee, J., Cua, D. IL-26 AMPs up the TH17 arsenal. Nat Immunol 16, 897–898 (2015).

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