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NLRP3 moonlights in TH2 polarization

Nature Immunology volume 16, pages 794–796 (2015)Cite this article

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As the cytosolic guardian for many microbial and sterile inflammatory insults, NLRP3 is best appreciated for its innate immunological role mediating inflammasome activation. Now NLRP3 debuts as a transcription factor key for TH2 polarization.

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Figure 1: In TH2 cells, NLRP3 forms a DNA-binding complex distinct from the inflammasomes.

Marina Corral Spence/Nature Publishing Group

References

  1. Bruchard, M. et al. Nat. Immunol. 16, 859–870 (2015).

    Article  CAS  Google Scholar 

  2. Li, P. et al. Nature 490, 543–546 (2012).

    Article  CAS  Google Scholar 

  3. Agostini, L. et al. Immunity 20, 319–325 (2004).

    Article  CAS  Google Scholar 

  4. Hu, Z. et al. Science 341, 172–175 (2013).

    Article  CAS  Google Scholar 

  5. Hake, S.B. et al. Mol. Cell. Biol. 20, 7716–7725 (2000).

    Article  CAS  Google Scholar 

  6. Locksley, R.M. Cell 140, 777–783 (2010).

    Article  CAS  Google Scholar 

  7. Kobayashi, M., Kobayashi, H., Pollard, R.B. & Suzuki, F. J. Immunol. 160, 5869–5873 (1998).

    CAS  PubMed  Google Scholar 

  8. van Deventer, H.W. et al. Cancer Res. 70, 10161–10169 (2010).

    Article  CAS  Google Scholar 

  9. Allen, I.C. et al. J. Immunol. 188, 2884–2893 (2012).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Departments of Genetics, Jenny P.Y. Ting is with the Lineberger Comprehensive Cancer Center, Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.,

    Jenny P Y Ting

  2. Jonathan A. Harton is with the Center for Immunology & Microbial Disease, Albany Medical College, Albany, New York, USA.,

    Jonathan A Harton

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  1. Jenny P Y Ting
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  2. Jonathan A Harton
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Correspondence to Jenny P Y Ting or Jonathan A Harton.

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The authors declare no competing financial interests.

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Ting, J., Harton, J. NLRP3 moonlights in TH2 polarization. Nat Immunol 16, 794–796 (2015). https://doi.org/10.1038/ni.3223

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