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How many memories does it take to make an SLE flare?

Nature Immunology volume 16, pages 685–687 (2015)Cite this article

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Deep-sequencing analyses of immunoglobulin variable-segment genes from antibody-secreting cells have allowed comparisons of conventional immunization responses to disease flares experienced by patients with systemic lupus erythematosus. Such analyses provide insight into B cell recruitment and differentiation processes yielding expanded clones that contribute to this complex autoimmune disease.

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Figure 1: The activation and reactivation of B cells in response to foreign antigens in control subjects and self antigens in patients with SLE.

Marina Corral Spence/Nature Publishing Group

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Authors and Affiliations

  1. David M. Tarlinton is with The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.,

    David M Tarlinton

  2. Kenneth G.C. Smith is in the Department of Medicine and Cambridge Institute of Medical Research, University of Cambridge School of Clinical Medicine, Cambridge, UK.,

    Kenneth G C Smith

Authors
  1. David M Tarlinton
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  2. Kenneth G C Smith
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Corresponding author

Correspondence to David M Tarlinton.

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Competing interests

D.M.T. and K.G.C.S. have consulted for UCB, which is developing epratuzumab for the treatment of SLE.

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Tarlinton, D., Smith, K. How many memories does it take to make an SLE flare?. Nat Immunol 16, 685–687 (2015). https://doi.org/10.1038/ni.3209

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