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How many memories does it take to make an SLE flare?

Nature Immunology volume 16, pages 685687 (2015) | Download Citation

Deep-sequencing analyses of immunoglobulin variable-segment genes from antibody-secreting cells have allowed comparisons of conventional immunization responses to disease flares experienced by patients with systemic lupus erythematosus. Such analyses provide insight into B cell recruitment and differentiation processes yielding expanded clones that contribute to this complex autoimmune disease.

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Author information

Affiliations

  1. David M. Tarlinton is with The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.

    • David M Tarlinton
  2. Kenneth G.C. Smith is in the Department of Medicine and Cambridge Institute of Medical Research, University of Cambridge School of Clinical Medicine, Cambridge, UK.

    • Kenneth G C Smith

Authors

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Competing interests

D.M.T. and K.G.C.S. have consulted for UCB, which is developing epratuzumab for the treatment of SLE.

Corresponding author

Correspondence to David M Tarlinton.

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DOI

https://doi.org/10.1038/ni.3209

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