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DNA methylation secures CD4+ and CD8+ T cell lineage borders

Dynamic control of DNA methylation in the Cd4 locus serves an important role in reinforcing the binary fate stability of helper and cytotoxic T cells.

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Figure 1: Epigenetic control of the stability of helper CD4+ and cytotoxic CD8+ T cell lineages.

Marina Corral Spence/Nature Publishing Group


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Correspondence to Alexander Y Rudensky.

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Feng, Y., Rudensky, A. DNA methylation secures CD4+ and CD8+ T cell lineage borders. Nat Immunol 16, 681–683 (2015).

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