Dynamic control of DNA methylation in the Cd4 locus serves an important role in reinforcing the binary fate stability of helper and cytotoxic T cells.
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Feng, Y., Rudensky, A. DNA methylation secures CD4+ and CD8+ T cell lineage borders. Nat Immunol 16, 681–683 (2015). https://doi.org/10.1038/ni.3207