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Sirt-ainly Aire

Nature Immunology volume 16, pages 680–681 (2015)Cite this article

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Sirtuin-1 (Sirt1), a protein deacetylase known for its multiple cellular functions, including roles in metabolism, stress response and aging, is a post-translational modulator of autoimmune regulator (Aire) in central immunotolerance.

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Figure 1: Aire upregulates tissue-restricted gene expression in medullary thymic epithelial cells (mTECs).

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  1. Pärt Peterson is at the Molecular Pathology Research Group, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.,

    Pärt Peterson

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  1. Pärt Peterson
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Correspondence to Pärt Peterson.

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Peterson, P. Sirt-ainly Aire. Nat Immunol 16, 680–681 (2015). https://doi.org/10.1038/ni.3195

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