Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Sirt-ainly Aire

Sirtuin-1 (Sirt1), a protein deacetylase known for its multiple cellular functions, including roles in metabolism, stress response and aging, is a post-translational modulator of autoimmune regulator (Aire) in central immunotolerance.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Aire upregulates tissue-restricted gene expression in medullary thymic epithelial cells (mTECs).

References

  1. Klein, L., Kyewski, B., Allen, P.M. & Hogquist, K.A. Nat. Rev. Immunol. 14, 377–391 (2014).

    Article  CAS  Google Scholar 

  2. Chuprin, A. et al. Nat. Immunol. 16, 737–745 (2015).

    Article  CAS  Google Scholar 

  3. Houtkooper, R.H., Pirinen, E. & Auwerx, J. Nat. Rev. Mol. Cell Biol. 13, 225–238 (2012).

    Article  CAS  Google Scholar 

  4. Abramson, J., Giraud, M., Benoist, C. & Mathis, D. Cell 140, 123–135 (2010).

    Article  CAS  Google Scholar 

  5. Gaetani, M. et al. Nucleic Acids Res. 40, 11756–11768 (2012).

    Article  CAS  Google Scholar 

  6. Oven, I. et al. Mol. Cell. Biol. 27, 8815–8823 (2007).

    Article  CAS  Google Scholar 

  7. Org, T. et al. EMBO Rep. 9, 370–376 (2008).

    Article  CAS  Google Scholar 

  8. Koh, A.S., Kingston, R.E., Benoist, C. & Mathis, D. Proc. Natl. Acad. Sci. USA 107, 13016–13021 (2010).

    Article  CAS  Google Scholar 

  9. Giraud, M. et al. Proc. Natl. Acad. Sci. USA 109, 535–540 (2012).

    Article  CAS  Google Scholar 

  10. Saare, M., Rebane, A., Rajashekar, B., Vilo, J. & Peterson, P. Exp. Cell Res. 318, 1767–1778 (2012).

    Article  CAS  Google Scholar 

  11. Bottomley, M.J. et al. Nat. Struct. Biol. 8, 626–633 (2001).

    Article  CAS  Google Scholar 

  12. Sequeira, J. et al. Exp. Cell Res. 314, 3069–3074 (2008).

    Article  CAS  Google Scholar 

  13. Beier, U.H. et al. Sci. Signal. 5, ra45 (2012).

    Article  Google Scholar 

  14. Zhang, J. et al. J. Clin. Invest. 119, 3048–3058 (2009).

    Article  CAS  Google Scholar 

  15. Biason-Lauber, A. et al. Cell Metab. 17, 448–455 (2013).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Pärt Peterson.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Peterson, P. Sirt-ainly Aire. Nat Immunol 16, 680–681 (2015). https://doi.org/10.1038/ni.3195

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ni.3195

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing