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TOX sets the stage for innate lymphoid cells

Like T cells and B cells, innate lymphoid cells (ILCs) develop from common lymphoid progenitors, but how commitment to the ILC lineage is regulated has remained unclear. The transcriptional regulator TOX is important in this process.

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Figure 1: Model for the development of NK cells, LTi cells and ILCs.

Katie Vicari/Nature Publishing Group

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Correspondence to Hergen Spits.

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Spits, H. TOX sets the stage for innate lymphoid cells. Nat Immunol 16, 594–595 (2015). https://doi.org/10.1038/ni.3177

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