Like T cells and B cells, innate lymphoid cells (ILCs) develop from common lymphoid progenitors, but how commitment to the ILC lineage is regulated has remained unclear. The transcriptional regulator TOX is important in this process.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
References
Artis, D. & Spits, H. Nature 517, 293–301 (2015).
Seehuis, C.R. et al. Nat. Immunol. 16, 599–608 (2015).
Diefenbach, A., Colonna, M. & Koyasu, S. Immunity 41, 354–365 (2014).
Klose, C.S. et al. Cell 157, 340–356 (2014).
Constantinides, M.G., McDonald, B.D., Verhoef, P.A. & Bendelac, A. Nature 508, 397–401 (2014).
Boos, M.D., Yokota, Y., Eberl, G. & Kee, B.L. J. Exp. Med. 204, 1119–1130 (2007).
Tindemans, I., Serafini, N., Di Santo, J.P. & Hendriks, R.W. Immunity 41, 191–206 (2014).
Wilkinson, B. et al. Nat. Immunol. 3, 272–280 (2002).
Aliahmad, P., de la Torre, B. & Kaye, J. Nat. Immunol. 11, 945–952 (2010).
Yu, X. et al. eLife 3, e04406 (2014).
Xu, W. et al. Cell Rep. 10, 2043–2054 (2015).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Spits, H. TOX sets the stage for innate lymphoid cells. Nat Immunol 16, 594–595 (2015). https://doi.org/10.1038/ni.3177
Published:
Issue Date:
DOI: https://doi.org/10.1038/ni.3177
This article is cited by
-
Cellular and molecular regulation of innate inflammatory responses
Cellular & Molecular Immunology (2016)