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TET1: an epigenetic guardian of lymphomagenesis

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Due to their role in regulating DNA-methylation patterns, the TET proteins, in particular TET2, have emerged as key participants in tumorigenesis. Now the spotlight shifts to TET1 and its role as a tumor suppressor in lymphomagenesis.

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Figure 1: The role of TET1 in regulating DNA methylation and hematopoiesis.

Katie Vicari/Nature Publishing Group

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Correspondence to Kristian Helin.

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Rasmussen, K., Helin, K. TET1: an epigenetic guardian of lymphomagenesis. Nat Immunol 16, 592–594 (2015). https://doi.org/10.1038/ni.3176

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