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Immune mechanisms at the maternal-fetal interface: perspectives and challenges

Leaders gathered at the US National Institutes of Health in November 2014 to discuss recent advances and emerging research areas in aspects of maternal-fetal immunity that may affect fetal development and pregnancy success.

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Figure 1: Classification of placentas based on histological assessment of the maternal-chorion interface.

Katie Vicari/Nature Publishing Group

Figure 2: Various immune cells interact with uterine and trophoblast cells during pregnancy.
Figure 3: Tolerance to the semiallogeneic fetus compared with organ transplantation.

Katie Vicari/Nature Publishing Group


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The authors thank P. Lenhart and D. Chakraborty for their time and effort in providing immunohistochemical sections for this article.

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Correspondence to Mercy PrabhuDas.

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PrabhuDas, M., Bonney, E., Caron, K. et al. Immune mechanisms at the maternal-fetal interface: perspectives and challenges. Nat Immunol 16, 328–334 (2015).

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