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A new receptor for LPS

Nature Immunology volume 16, pages 340–341 (2015)Cite this article

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A surface-localized lectin S-domain receptor kinase confers recognition of lipopolysaccharide in plants.

The innate immune system's ability to recognize infectious non-self molecules relies on the sensitive perception of conserved pathogen-associated molecular patterns (PAMPs) by host pattern-recognition receptors (PRRs). A stereotypical bacterial PAMP recognized by mammalian cells is lipopolysaccharide (LPS)1, the major constituent of the outer cell envelope of Gram-negative bacteria. Although plants are also able to perceive LPS and mount innate immune responses2,3,4, no plant receptor for LPS was known until now. In this issue of Nature Immunology, Ranf et al.5 report the identification of a plasma-membrane receptor kinase that is required for responsiveness to LPS in plants and define a type of domain potentially involved in the perception of LPS.

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Figure 1: The recognition of LPS in mammals and plants.

Katie Vicari/Nature Publishing Group

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  1. Cyril Zipfel is at The Sainsbury Laboratory, Norwich Research Park, Norwich, UK.,

    Cyril Zipfel

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  1. Cyril Zipfel
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Correspondence to Cyril Zipfel.

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Zipfel, C. A new receptor for LPS. Nat Immunol 16, 340–341 (2015). https://doi.org/10.1038/ni.3127

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