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LincRNA signatures in human lymphocytes

Nature Immunology volume 16, pages 220–222 (2015)Cite this article

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Sequencing studies have provided a comprehensive catalog of the expression of intergenic long noncoding RNAs (lincRNAs) in 13 subsets of human T cells and B cells. Subtype-selective lincRNAs are among those identified, including linc-MAF-4, that might regulate T cell differentiation.

It is now widely accepted that the microRNA family of short noncoding RNAs has an important regulatory role in almost all aspects of the immune response, including the proliferation, differentiation and activation of cells of the immune system1. In contrast, little is known about long noncoding RNAs (lncRNAs), tens of thousands of which have been identified by high-throughput sequencing. To address this issue, Ranzani et al. have catalogued the expression of intergenic lncRNAs (lincRNAs) in 13 subtypes of human T cells and B cells, from which they have identified a group of 180 lincRNAs that are subtype selective2. Notably, they show that a member of this group, linc-MAF-4, promotes a CD4+ T helper type 1 (TH1) phenotype by acting in cis to suppress the expression of MAF, which encodes the CD4+ TH2 cell–promoting transcription factor c-Maf.

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Figure 1: The expression of lincRNAs in human lymphocyte populations.

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  1. Benoit T. Roux and Mark A. Lindsay are in the Department of Pharmacy and Pharmacology, University of Bath, Bath, UK.

    Benoit T Roux & Mark A Lindsay

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  1. Benoit T Roux
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  2. Mark A Lindsay
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Correspondence to Mark A Lindsay.

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The authors declare no competing financial interests.

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Roux, B., Lindsay, M. LincRNA signatures in human lymphocytes. Nat Immunol 16, 220–222 (2015). https://doi.org/10.1038/ni.3106

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