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GPR15: a tale of two species

Nature Immunology volume 16, pages 137–139 (2015)Cite this article

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The chemoattractant receptor GPR15 directs the homing of T cells to the colon; however, GRP15 expression differs in the effector and regulatory T cell subsets of humans versus those of mice. These findings have profound implications for the potential targeting of GRP15 for therapeutic intervention.

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Figure 1: Divergent expression of GPR15 in subsets of Teff cells and Treg cells in humans and mice.

Marina Corral Spence/Nature Publishing Group

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Authors and Affiliations

  1. Janine Bilsborough is with the F. Widjaja Foundation Inflammatory Bowel and Immunobiology Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.,

    Janine Bilsborough

  2. Joanne L. Viney is with Immunology Research, Biogen Idec, Cambridge, Massachusetts, USA.,

    Joanne L Viney

Authors
  1. Janine Bilsborough
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  2. Joanne L Viney
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Corresponding author

Correspondence to Joanne L Viney.

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Competing interests

J.L.V. is employed by Biogen Idec.

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Bilsborough, J., Viney, J. GPR15: a tale of two species. Nat Immunol 16, 137–139 (2015). https://doi.org/10.1038/ni.3084

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