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Broad and strong: the ultimate antibody to dengue virus

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The identification of a new class of cross-reactive monoclonal antibodies that strongly neutralize all four serotypes of dengue virus has important implications for vaccine design as well as for the evaluation of vaccines and of natural infection with dengue virus.

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Figure 1: Potently neutralizing human DENV-specific antibodies after primary and secondary DENV infection.

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Correspondence to Eva Harris.

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Coloma, J., Harris, E. Broad and strong: the ultimate antibody to dengue virus. Nat Immunol 16, 135–137 (2015). https://doi.org/10.1038/ni.3081

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