The identification of a new class of cross-reactive monoclonal antibodies that strongly neutralize all four serotypes of dengue virus has important implications for vaccine design as well as for the evaluation of vaccines and of natural infection with dengue virus.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Dejnirattisai, W. et al. Nat. Immunol. 16, 170–177 (2015).
Pierson, T.C. & Diamond, M.S. Curr. Opin. Virol. 2, 168–175 (2012).
Tsai, W.-Y. et al. J. Virol. 87, 12562–12575 (2013).
Smith, S.A. et al. J. Virol. 86, 2665–2675 (2012).
Cherrier, M.V. et al. EMBO J. 28, 3269–3276 (2009).
de Alwis, R. et al. PLoS Negl. Trop. Dis. 5, e1188 (2011).
Beltramello, M. et al. Cell Host Microbe 8, 271–283 (2010).
Dejnirattisai, W. et al. Science 328, 745–748 (2010).
de Alwis, R. et al. Proc. Natl. Acad. Sci. USA 109, 7439–7444 (2012).
Teoh EP. et al. Sci. Transl. Med. 4, 139ra183 (2012).
Fibriansah, G. et al. EMBO Mol. Med. 6, 358–371 (2013).
Xu, M. et al. J. Immunol. 189, 5877–5885 (2012).
Smith SA. et al. mBio 2013, 4, e00873–00813.
Wahala, W.M. et al. J. Virol. 86, 4019–4023 (2012).
VanBlargan, L.A. et al. PLoS Pathog. 9, e1003761 (2013).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Coloma, J., Harris, E. Broad and strong: the ultimate antibody to dengue virus. Nat Immunol 16, 135–137 (2015). https://doi.org/10.1038/ni.3081
Published:
Issue Date:
DOI: https://doi.org/10.1038/ni.3081
This article is cited by
-
Neutralization of Zika virus by germline-like human monoclonal antibodies targeting cryptic epitopes on envelope domain III
Emerging Microbes & Infections (2017)