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Systematic analysis of immunodeficiency

Humans deficient in the adaptor MyD88 or the kinase IRAK4 suffer from primary immunodeficiency. Blood cells from these patients show defective induction of specific subsets of genes after exposure to microbial stimuli in vitro.

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Figure 1: Modular approach to the evaluation of changes in gene expression.


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Correspondence to David F Tough.

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The author is an employee of GlaxoSmithKline.

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Tough, D. Systematic analysis of immunodeficiency. Nat Immunol 15, 1097–1098 (2014).

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