Skin DCs cluster for efficient T cell activation

Clusters of dermal dendritic cells and T cells are required for efficient activation of T cells in skin following hapten sensitization via a process dependent on interleukin 1α (IL-1α) and the chemokine CXCL2 produced by macrophages.

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Figure 1: A model for macrophage-orchestrated T cell–DC clustering in the skin during inflammation.

Kim Caesar/Nature Publishing Group

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Correspondence to Scott N Mueller.

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Mueller, S. Skin DCs cluster for efficient T cell activation. Nat Immunol 15, 1004–1005 (2014). https://doi.org/10.1038/ni.3012

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