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Breaking barriers: a GPCR triggers immunity in nematodes

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A ligand and G protein–coupled receptor activate antimicrobial gene expression in the Caenorhabditis elegans epidermis, in response to wounding and to infection with a fungal pathogen.

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Figure 1: Epithelial cell defense mediated by the p38 pathway in C. elegans.

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Correspondence to Emily R Troemel.

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Luallen, R., Troemel, E. Breaking barriers: a GPCR triggers immunity in nematodes. Nat Immunol 15, 826–828 (2014). https://doi.org/10.1038/ni.2963

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