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An antitumor boost to TH9 cells

Cells of the TH9 subset of helper T cells differentiated in the presence of interleukin 1β (IL-1β) produce large amounts of IL-9 and IL-21 in a manner dependent on the transcription factors STAT1 and IRF1 and exhibit potent anticancer effects.

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Figure 1: IL-1β promotes the differentiation of TH9 cells that secrete large amounts of IL-9 and IL-21, in a manner dependent on STAT1 and IRF1.

Debbie Maizels/Nature Publishing Group

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Correspondence to Sergio A Quezada.

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Quezada, S., Peggs, K. An antitumor boost to TH9 cells. Nat Immunol 15, 703–705 (2014). https://doi.org/10.1038/ni.2945

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