Cells of the TH9 subset of helper T cells differentiated in the presence of interleukin 1β (IL-1β) produce large amounts of IL-9 and IL-21 in a manner dependent on the transcription factors STAT1 and IRF1 and exhibit potent anticancer effects.
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References
Mosmann, T.R. et al. J. Immunol. 136, 2348–2357 (1986).
Fontenot, J.D., Gavin, M.A. & Rudensky, A.Y. Nat. Immunol. 4, 330–336 (2003).
Crotty, S. Annu. Rev. Immunol. 29, 621–663 (2011).
Bettelli, E. et al. Nature 441, 235–238 (2006).
Dardalhon, V. et al. Nat. Immunol. 9, 1347–1355 (2008).
Veldhoen, M. et al. Nat. Immunol. 9, 1341–1346 (2008).
Végran, F. et al. Nat. Immunol. 15, 758–766 (2014).
Jager, A. J. Immunol. 183, 7169–7177 (2009).
Staudt, V. et al. Immunity 33, 192–202 (2010).
Chang, H.C. et al. Nat. Immunol. 11, 527–534 (2010).
Taki, S. et al. Immunity 6, 673–679 (1997).
Lohoff, M. et al. Immunity 6, 681–689 (1997).
Purwar, R. et al. Nat. Med. 18, 1248–1253 (2012).
Lee, Y.K. et al. Immunity 30, 92–107 (2009).
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Quezada, S., Peggs, K. An antitumor boost to TH9 cells. Nat Immunol 15, 703–705 (2014). https://doi.org/10.1038/ni.2945
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DOI: https://doi.org/10.1038/ni.2945
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