Commentary | Published:

Toward a Human Vaccines Project

Nature Immunology volume 15, pages 589592 (2014) | Download Citation

Subjects

Technological advances in antigen discovery, genomics and immunological monitoring offer tremendous potential for revolutionizing vaccine development. On 5–6 February 2014, 35 leading vaccine scientists met to consider how best to harness these advances and spur innovation.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    Centers for Disease Control and Prevention. MMWR Morb. Mortal. Wkly. Rep. 48, 621–629 (1999).

  2. 2.

    US Food and Drug Administration. Vaccines, Blood & Biologics. (2013).

  3. 3.

    N. Engl. J. Med. 368, 551–560 (2013).

  4. 4.

    , , & Pediatr. Infect. Dis. J. 24, S58–S61 (2005).

  5. 5.

    et al. Vaccine 31, B209–B215 (2013).

  6. 6.

    et al. Curr. Top. Med. Chem. 13, 2541–2550 (2013).

  7. 7.

    & Curr. Opin. Infect. Dis. 24, 190–195 (2011).

  8. 8.

    et al. Vaccine 29, 1242–1247 (2011).

  9. 9.

    & Clin. Microbiol. Infect. 17, 1600–1607 (2011).

  10. 10.

    , , & Expert Rev. Vaccines 12, 1431–1448 (2013).

  11. 11.

    Curr. Med. Chem. (5 February 2014).

  12. 12.

    et al. Science 340, 1232910 (2013).

  13. 13.

    & Immunity 33, 530–541 (2010).

  14. 14.

    , , & Science 337, 183–186 (2012).

  15. 15.

    et al. Nature 507, 201–206 (2014).

  16. 16.

    , , & Nat. Biotechnol. 30, 423–433 (2012).

  17. 17.

    , & Nat. Rev. Immunol. 13, 693–701 (2013).

  18. 18.

    et al. Science 342, 592–598 (2013).

  19. 19.

    et al. Proc. Natl. Acad. Sci. USA 109, 14604–14609 (2012).

  20. 20.

    et al. Nature 473, 523–527 (2011).

  21. 21.

    , & Curr Opin HIV AIDS 8, 401–410 (2013).

  22. 22.

    , & Anal. Chem. 82, 9090–9099 (2010).

  23. 23.

    et al. Nat. Immunol. 10, 116–125 (2009).

  24. 24.

    et al. Science 343, 313–317 (2014).

  25. 25.

    et al. Nat. Immunol. 15, 195–204 (2014).

  26. 26.

    & Annu. Rev. Immunol. 31, 705–742 (2013).

  27. 27.

    et al. Nature 496, 469–476 (2013).

  28. 28.

    et al. Science 333, 1593–1602 (2011).

  29. 29.

    , , , & Immunity 36, 142–152 (2012).

Download references

Acknowledgements

We thank the Human Vaccines Project Working Group, which included Alan Aderem (Seattle Biomed), Rafi Ahmed (Emory Vaccine Center), Deborah Bae (Robert Wood Johnson Foundation), Ripley Ballou (GlaxoSmithKline), Maharaj K. Bhan (India Department of Biotechnology), Ashley Birkett (PATH Malaria Vaccine Initiative), Dennis Burton (The Scripps Research Institute), Danny Casimiro (Merck), Shane Crotty (La Jolla Institute of Allergy and Immunology), James Crowe (Vanderbilt University School of Medicine), Mark Davis (Stanford University School of Medicine), Hansi Dean (International AIDS Vaccine Initiative (IAVI)), Nathalie Garcon (GlaxoSmithKline), Ann Ginsberg (Aeras), Hana Golding (FDA), Rajat Goyal (IAVI), Barney Graham (National Institute of Allergy and Infectious Diseases (NIAID) Vaccine Research Center), Sanjay Gurunathan (Sanofi), Ian Gust (University of Melbourne), Barton F. Haynes (Duke Human Vaccine Institute, Duke University), Carole Heilman (Federal Liaison, NIAID), Adrian Hill (The Jenner Institute), Wayne Koff (IAVI), Antonio Lanzavecchia (Institute for Research in Biomedicine), John Mascola (NIAID Vaccine Research Center), Julie McElrath (Fred Hutchinson Cancer Research Center), Douglas Nixon (George Washington University), Stanley Plotkin (Vaxconsult), Bali Pulendran (Emory Vaccine Center), Ellis Reinherz (Dana Farber Cancer Institute, Harvard University), Bill Schief (IAVI Neutralizing Antibody Center at The Scripps Research Institute), Robert Seder (NIAID Vaccine Research Center), Mark Slifka (Oregon Health and Science University) and Chris Wilson (Bill & Melinda Gates Foundation); H. Dean, O. Shmaidenko and T. Schenkelberg for coordinating summary reports from group discussions in the workshop; L. Gieber for accessing 'pre-read' materials for the workshop; and S. Glass for logistics and organizational support for the workshop. Support for the Human Vaccines Project workshop was provided by a grant to IAVI (W.C.K.) from the Robert Wood Johnson Foundation.

Author information

Affiliations

  1. Wayne C. Koff is with the International AIDS Vaccine Initiative, New York, New York, USA.

    • Wayne C Koff
  2. Ian D. Gust is in the Department of Microbiology and Immunology, University of Melbourne, Parkville, Australia.

    • Ian D Gust
  3. Stanley A. Plotkin is with the University of Pennsylvania, Philadelphia, Pennsylvania, USA, and Vaxconsult, Doylestown, Pennsylvania, USA.

    • Stanley A Plotkin

Authors

  1. Search for Wayne C Koff in:

  2. Search for Ian D Gust in:

  3. Search for Stanley A Plotkin in:

Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Wayne C Koff.

About this article

Publication history

Published

DOI

https://doi.org/10.1038/ni.2871

Further reading

Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing