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TACTILE becomes tangible: CD96 discloses its inhibitory peculiarities

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The receptor CD96 inhibits cytokine production by natural killer cells in mice and antagonizes activation mediated by the receptor CD226.

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Figure 1: The interactions of CD155 with CD96, CD226 and TIGIT trigger various cellular responses.

References

  1. Wang, P.L. et al. J. Immunol. 148, 2600–2608 (1992).

    CAS  PubMed  Google Scholar 

  2. Fuchs, A. et al. J. Immunol. 172, 3994–3998 (2004).

    Article  CAS  Google Scholar 

  3. Chan, C.J. et al. Nat. Immunol. 15, 431–438 (2014).

    Article  CAS  Google Scholar 

  4. Maier, M.K. et al. Eur. J. Immunol. 37, 2214–2225 (2007).

    Article  CAS  Google Scholar 

  5. Shibuya, K. et al. Immunity 11, 615–623 (1999).

    Article  CAS  Google Scholar 

  6. Shibuya, K. et al. J. Exp. Med. 198, 1829–1839 (2003).

    Article  CAS  Google Scholar 

  7. Joller, N. et al. J. Immunol. 186, 1338–1342 (2011).

    Article  CAS  Google Scholar 

  8. Levin, S.D. et al. Eur. J. Immunol. 41, 902–915 (2011).

    Article  CAS  Google Scholar 

  9. Stanietsky, N. et al. Proc. Natl. Acad. Sci. USA 106, 17858–17863 (2009).

    Article  CAS  Google Scholar 

  10. Stanietsky, N. et al. Eur. J. Immunol. 43, 2138–2150 (2013).

    Article  CAS  Google Scholar 

  11. Oda, T., Ohka, S. & Nomoto, A. Biochem. Biophys. Res. Commun. 319, 1253–1264 (2004).

    Article  CAS  Google Scholar 

  12. Yu, X. et al. Nat. Immunol. 10, 48–57 (2009).

    Article  CAS  Google Scholar 

  13. Koike, S. et al. EMBO J. 9, 3217–3224 (1990).

    Article  CAS  Google Scholar 

  14. Meyer, D. et al. J. Biol. Chem. 284, 2235–2244 (2009).

    Article  CAS  Google Scholar 

  15. Seth, S. et al. Biochem. Biophys. Res. Commun. 364, 959–965 (2007).

    Article  CAS  Google Scholar 

  16. Gramatzki, M. et al. Exp. Hematol. 26, 1209–1214 (1998).

    CAS  PubMed  Google Scholar 

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Correspondence to Günter Bernhardt.

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Bernhardt, G. TACTILE becomes tangible: CD96 discloses its inhibitory peculiarities. Nat Immunol 15, 406–408 (2014). https://doi.org/10.1038/ni.2855

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