In addition to its canonical role in reverse cholesterol transport, high-density lipoprotein can suppress inflammation in target cells through the induction of Atf3, which encodes a well-known transcriptional repressor.
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Odegaard, J., Chawla, A. Old HDL learns a new (anti-inflammatory) trick. Nat Immunol 15, 138–139 (2014). https://doi.org/10.1038/ni.2798
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DOI: https://doi.org/10.1038/ni.2798