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Old HDL learns a new (anti-inflammatory) trick

In addition to its canonical role in reverse cholesterol transport, high-density lipoprotein can suppress inflammation in target cells through the induction of Atf3, which encodes a well-known transcriptional repressor.

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Figure 1: HDL suppresses TLR ligand–induced inflammation via activation of Atf3.

Marina Corral Spence

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Correspondence to Ajay Chawla.

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Odegaard, J., Chawla, A. Old HDL learns a new (anti-inflammatory) trick. Nat Immunol 15, 138–139 (2014). https://doi.org/10.1038/ni.2798

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