Studies have linked polymorphisms near the gene encoding interferon-λ3 (IFNL3) to clearance of hepatitis C virus (HCV). One such favorable polymorphism operates by stabilizing IFNL3 mRNA via a decrease in AU-rich element–mediated decay as well as the binding of HCV-induced host microRNAs.
This is a preview of subscription content, access via your institution
Subscribe to this journal
Receive 12 print issues and online access
$189.00 per year
only $15.75 per issue
Rent or buy this article
Get just this article for as long as you need it
Prices may be subject to local taxes which are calculated during checkout
Suppiah, V. et al. Nat. Genet. 41, 1100–1104 (2009).
Tanaka, Y. et al. Nat. Genet. 41, 1105–1109 (2009).
Ge, D. et al. Nature 461, 399–401 (2009).
Thomas, D.L. et al. Nature 461, 798–801 (2009).
McFarland, A. et al. Nat. Immunol. 15, 72–79 (2014).
Thomas, D.L. Nat. Med. 19, 850–858 (2013).
Rehermann, B. Nat. Med. 19, 859–868 (2013).
Lanford, R.E. et al. Science 327, 198–201 (2010).
Janssen, H.L. et al. N. Engl. J. Med. 368, 1685–1694 (2013).
Knapp, S. et al. Hepatology 51, 1168–1175 (2010).
Rehermann, B. & Nascimbeni, M. Nat. Rev. Immunol. 5, 215–229 (2005).
Arzumanyan, A., Reis, H.M. & Feitelson, M.A. Nat. Rev. Cancer 13, 123–135 (2013).
Holder, K.A., Stapleton, S.N., Gallant, M.E., Russell, R.S. & Grant, M.D. J. Immunol. 191, 3308–3318 (2013).
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Tian, Z. Outflanking HCV. Nat Immunol 15, 6–8 (2014). https://doi.org/10.1038/ni.2783