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Outflanking HCV


Studies have linked polymorphisms near the gene encoding interferon-λ3 (IFNL3) to clearance of hepatitis C virus (HCV). One such favorable polymorphism operates by stabilizing IFNL3 mRNA via a decrease in AU-rich element–mediated decay as well as the binding of HCV-induced host microRNAs.

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Figure 1: The role of HCV-induced miRNAs in HCV clearance.


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Correspondence to Zhigang Tian.

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The author declares no competing financial interests.

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Tian, Z. Outflanking HCV. Nat Immunol 15, 6–8 (2014).

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