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Outflanking HCV


Studies have linked polymorphisms near the gene encoding interferon-λ3 (IFNL3) to clearance of hepatitis C virus (HCV). One such favorable polymorphism operates by stabilizing IFNL3 mRNA via a decrease in AU-rich element–mediated decay as well as the binding of HCV-induced host microRNAs.

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Figure 1: The role of HCV-induced miRNAs in HCV clearance.


  1. 1

    Suppiah, V. et al. Nat. Genet. 41, 1100–1104 (2009).

    CAS  Article  Google Scholar 

  2. 2

    Tanaka, Y. et al. Nat. Genet. 41, 1105–1109 (2009).

    CAS  Article  Google Scholar 

  3. 3

    Ge, D. et al. Nature 461, 399–401 (2009).

    CAS  Article  Google Scholar 

  4. 4

    Thomas, D.L. et al. Nature 461, 798–801 (2009).

    CAS  Article  Google Scholar 

  5. 5

    McFarland, A. et al. Nat. Immunol. 15, 72–79 (2014).

    CAS  Article  Google Scholar 

  6. 6

    Thomas, D.L. Nat. Med. 19, 850–858 (2013).

    CAS  Article  Google Scholar 

  7. 7

    Rehermann, B. Nat. Med. 19, 859–868 (2013).

    CAS  Article  Google Scholar 

  8. 8

    Lanford, R.E. et al. Science 327, 198–201 (2010).

    CAS  Article  Google Scholar 

  9. 9

    Janssen, H.L. et al. N. Engl. J. Med. 368, 1685–1694 (2013).

    CAS  Article  Google Scholar 

  10. 10

    Knapp, S. et al. Hepatology 51, 1168–1175 (2010).

    CAS  Article  Google Scholar 

  11. 11

    Rehermann, B. & Nascimbeni, M. Nat. Rev. Immunol. 5, 215–229 (2005).

    CAS  Article  Google Scholar 

  12. 12

    Arzumanyan, A., Reis, H.M. & Feitelson, M.A. Nat. Rev. Cancer 13, 123–135 (2013).

    CAS  Article  Google Scholar 

  13. 13

    Holder, K.A., Stapleton, S.N., Gallant, M.E., Russell, R.S. & Grant, M.D. J. Immunol. 191, 3308–3318 (2013).

    CAS  Article  Google Scholar 

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Correspondence to Zhigang Tian.

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The author declares no competing financial interests.

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Tian, Z. Outflanking HCV. Nat Immunol 15, 6–8 (2014).

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