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Kinases conquer the inflammasomes

Nature Immunology volume 14, pages 1207–1208 (2013)Cite this article

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Inflammasomes are signaling platforms of the innate immune system that activate proinflammatory cytokines after microbial pathogens are sensed or sterile danger is detected. The kinases Syk and Jnk control inflammasome activation by mediating phosphorylation of the inflammasome adaptor ASC.

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Figure 1: The regulation of inflammasome activation by kinases.

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Authors and Affiliations

  1. Konstantin Neumann and Jürgen Ruland are with the Institut für Klinische Chemie und Pathobiochemie, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.,

    Konstantin Neumann & Jürgen Ruland

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  1. Konstantin Neumann
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  2. Jürgen Ruland
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Correspondence to Jürgen Ruland.

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The authors declare no competing financial interests.

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Neumann, K., Ruland, J. Kinases conquer the inflammasomes. Nat Immunol 14, 1207–1208 (2013). https://doi.org/10.1038/ni.2763

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