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Bypassing T cell 'exhaustion'

The hypoxia-inducible factor (HIF) pathway controls diverse aspects of the immunological response. Enhanced HIF activity is able to extend and potentiate the effector response of CD8+ T cells against chronic infections and tumor growth.

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Figure 1: Enhanced HIF signaling drives an activated effector fate of CD8+ T cells and counteracts exhaustion in response to chronic exposure to antigen.

Katie Vicari

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Correspondence to Joachim R Göthert.

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Göthert, J. Bypassing T cell 'exhaustion'. Nat Immunol 14, 1114–1116 (2013). https://doi.org/10.1038/ni.2742

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