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No antigen-presentation defect in Unc93b13d/3d (3d) mice

Nature Immunology volume 14, pages 1101–1102 (2013)Cite this article

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To the Editor:

Unc93b1 is a critical regulator of signaling by Toll-like receptors (TLRs)1. The original description of mice with an inactivating mutation in Unc93b1 (encoding Unc93b1 with substitution of arginine for the histidine at position 412 (H412R); also called '3d mice') reported that these mice have defective signaling via TLR3, TLR7 and TLR9 as well as defects in presentation by major histocompatibility complex (MHC) class II and in cross-presentation1. Mutations in Unc93b1 have also been identified as a genetic etiological factor in the encephalitis caused by herpes simplex virus type 1; susceptibility to this encephalitis is associated with defects in TLR signaling2. Notably, in vitro studies of human cells have not found defects in presentation by MHC class II after knockdown of Unc93b1 (ref. 3), which raises the possibility that the role of Unc93b1 in antigen presentation, at least for MHC class II, is limited to mice. Further studies have shown that Unc93b1 controls TLR signaling by acting as a trafficking chaperone, associating with TLRs (such as TLR3, TLR7, TLR8, TLR9, TLR11 and TLR13) and delivering them from the endoplasmic reticulum to endosomes4,5,6. On the other hand, despite ample studies of mice homozygous for the 3d mutation (Unc93b13d/3d mice), mechanistic understanding of the role of Unc93b1 in antigen presentation is still lacking.

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Figure 1: Antigen presentation is unaffected in Unc93b13d/3d mice.

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Acknowledgements

We thank members of the Barton laboratory for critical reading of the manuscript; G.L. Reiner and B.R. Russell for technical assistance with experiments; and H. Nolla for assistance with flow cytometry. Supported by the US National Institutes of Health (AI072429 and AI063302), the Lupus Research Institute (G.M.B.), the Human Frontier Science Program (J.D.) and the Philippe Foundation (J.D.).

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  1. Division of Immunology & Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, USA

    Jacques Deguine, Bettina L Lee, Zachary R Newman & Gregory M Barton

Authors
  1. Jacques Deguine
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  2. Bettina L Lee
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  3. Zachary R Newman
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  4. Gregory M Barton
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Contributions

J.D. and G.M.B. designed research and analyzed data; B.L.L. and Z.R.N. did preliminary studies; J.D. did the experiments presented here; and J.D. and G.M.B. wrote the manuscript.

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Correspondence to Gregory M Barton.

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The authors declare no competing financial interests.

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Deguine, J., Lee, B., Newman, Z. et al. No antigen-presentation defect in Unc93b13d/3d (3d) mice. Nat Immunol 14, 1101–1102 (2013). https://doi.org/10.1038/ni.2733

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